MORINGA OLEIFERA CRUDE EXTRACT AND THE REFERENCE M2-CHANNEL BLOCKER AMANTADINE AS ANTIVIRALS AGAINST THE EGYPTIAN H5N8 ISOLATE, SPECIFICALLY INFLUENZA A/CHICKEN/EGYPT/Q16684C/2019 (H5N8) VIRUS.
نویسندگان
چکیده
منابع مشابه
Genesis of Influenza A(H5N8) Viruses
Highly pathogenic avian influenza A(H5N8) clade 2.3.4.4 virus emerged in 2016 and spread to Russia, Europe, and Africa. Our analysis of viruses from domestic ducks at Tanguar haor, Bangladesh, showed genetic similarities with other viruses from wild birds in central Asia, suggesting their potential role in the genesis of A(H5N8).
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Structures of truncated versions of the influenza A virus M2 proton channel have been determined recently by x-ray crystallography in the open conformation of the channel, and by NMR in the closed state. The structures differ in the position of the bound inhibitors. The x-ray structure shows a single amantadine molecule in the middle of the channel, whereas in the NMR structure four drug molecu...
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Structures of the influenza A virus M2 proton channel in the open conformation have been determined by X-ray crystallography, and in the closed conformation by NMR. Whereas the X-ray structure shows a single inhibitor molecule in the middle of the channel, four inhibitor molecules bind the channel's outer surface in the NMR structure. In both structures, the strongest hot spots (i.e., regions t...
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Amantadine is known to block the M2 proton channel of the Influenza A virus. Here, we present a structure of the M2 trans-membrane domain blocked with amantadine, built using orientational constraints obtained from solid-state NMR polarization-inversion-spin-exchange-at-the-magic-angle experiments. The data indicates a kink in the monomer between two helical fragments having 20 degrees and 31 d...
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BACKGROUND The incidence of lung cancer is expected to increase due to increases in exposure to airborne pollutants and cigarette smoke. Moringa oleifera (MO), a medicinal plant found mainly in Asia and South Africa is used in the traditional treatment of various ailments including cancer. This study investigated the antiproliferative effect of MO leaf extract (MOE) in cancerous A549 lung cells...
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ژورنال
عنوان ژورنال: Al-Azhar Journal of Pharmaceutical Sciences
سال: 2022
ISSN: ['1110-1644', '2535-1958']
DOI: https://doi.org/10.21608/ajps.2022.269249